Hamna from Multan was 5 months old when, in March 2010, she was diagnosed with β-thalassemia major and given first blood transfusion. She required blood transfusion every month and developed iron overload. Iron chelation therapy was started at the age of 2 years. Fahad, Hamna’s younger brother, was HLA matched with his sister. The family reported at AFBMTC in February 2013 for transplant. As Hamna was in Pesro Class-III, modified long protocol with thiotepa was given for pre-transplant conditioning. Hamna underwent bone marrow transplant on 14 March 2014 at the age of 4 years. Her donor was just 2¼ years of age. Almost 3 years after her transplant, Hamna is off all medications. She is 7 years old now and studies in class 2. She visits AFBMTC at 6 monthly intervals for checkup. Fahad, Hamna’s bone marrow donor is now 5 years of age and enjoys his sister’s company.